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Biochemical and pain biomarkers can be applied to patients with painful osteoarthritis profiles and may provide more details compared with conventional clinical tools. The aim of this study was to identify an optimal combination of biochemical and pain biomarkers for classification of patients with ...
January 1, 2015
Clin J Pain
Egsgaard LL, Eskehave TN, Bay-Jensen AC, Hoeck HC, Arendt-Nielsen L
Background: Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. Hypertrophy-like changes have been observed as part of the progression of OA. The aim of the study was to develop and characterize a novel biomarker of chondrocytes hy...
September 22, 2014
BMC Musculoskelet Disord
He Y, Siebuhr AS, Brandt-Hansen NU, Wang J, Su D, Zheng Q, Simonsen O, Petersen KK, Arendt-Nielsen L, Hoeck HC, Karsdal MA, Bay-Jensen AC, Eskehave TN
OBJECTIVE:To assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain METHODS:The study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using the Kell...
August 28, 2014
Arendt-Nielsen L, Eskehave TN, Egsgaard LL, Petersen KK, Graven-Nielsen T, Hoeck HC, Simonsen O, Siebuhr AS, Karsdal MA, Bay-Jensen AC
Objectives: Osteoarthritis (OA) is a degenerative disease with a subset of patients experiencing joint inflammation, but C-reactive protein (CRP) has shown limited use in OA as a diagnostic marker. The aim was to identify subpopulations of patients with high or low levels of acute (high sensitive CR...
January 7, 2014
Siebuhr AS, Petersen KK, Arendt-Nielsen L, Egsgaard LL, Christiansen C, Simonsen O, Hoeck HC, Karsdal MA, Eskehave TN
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