Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-treated rats and patients with PF and analysed the effects of ...
August 4, 2022
Journal:
Respiratory Research
Author:
Hesse C, Beneke V, Konzok S, Diefenbach C, Bülow Sand JM, Rønnow S, Karsdal MA, Jonigk D, Sewald K, Braun A, Leeming DJ, Wollin L
Chronic obstructive pulmonary disease (COPD) is characterized by high levels of protease activity leading to degradation of elastin followed by loss of elasticity of the lung and the development of emphysema. Elastin is an essential structural component of the lung parenchyma to support the expansio...
September 10, 2018
Journal:
Biochem Biophys Res Commun
Author:
Gudmann NS, Manon-Jensen T, Diefenbach C, Sun S, Danielsen A, Karsdal MA, Leeming DJ, Bülow Sand JM
Background: During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin. We selected specific elastin fragments generated by NE for ant...
May 3, 2015
Journal:
BMC Pulm Med.
Author:
Kristensen JH, Karsdal MA, Willumsen N, Diefenbach C, Svensson B, Hägglund P, Leeming DJ, Bülow Sand JM
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