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Background: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention. Objective: I...
May 5, 2021
Journal:
J Intern Med
Author:
Holm Nielsen S, Edsfeldt A, Tengryd C, Gustafsson H, Shore CA, Natali A, Khan F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I, Genovese F
Background and aims: A vulnerable plaque is an atherosclerotic plaque that is rupture-prone with a higher risk to cause cardiovascular symptoms such as myocardial infarction or stroke. Mimecan or osteoglycin is a small leucine-rich proteoglycan, important for collagen fibrillogenesis, that has been ...
November 25, 2020
Journal:
atherosclerosis
Author:
Tengryd C, Nielsen SH, Cavalera M, Bengtsson E, Genovese F, Dunér P, Orho-Melander M, Nilsson J, Edsfeldt A, Gonçalves I, Karsdal MA
Background: Patients with atherosclerosis have a high risk of cardiovascular events and death. Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix proteins in the intima. We hypothesized that dysregulated remodeling of the basement membrane proteins may be asso...
November 6, 2018
Journal:
J am heart assoc
Author:
Nielsen SH, Tengryd C, Edsfeldt A, Brix S, Genovese F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I
OBJECTIVE: Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explore...
August 28, 2018
Journal:
J Intern Med
Author:
Holm Nielsen S, Tengryd C, Edsfeldt A, Genovese F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I
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