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Background: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood. Aim: We studied the interplay between weight change and risk of hype...
March 6, 2017
Journal:
Aging Clin Exp Res
Author:
Dragsbæk K, Neergaard JS, Christiansen C, Karsdal MA, Beck-Nielsen H, Brix S, Henriksen K
The prognostic value of the metabolic syndrome (MetS) is believed to vary with age. With an elderly population expecting to triple by 2060, it is important to evaluate the validity of MetS in this age group. We examined the association of MetS risk factors with later risk of type 2 diabetes (T2DM) a...
September 15, 2016
Journal:
Medicine (Baltimore)
Author:
Dragsbæk K", Neergaard JS, Laursen JM, Hansen HB, Christiansen C, Beck-Nielsen H, Karsdal MA, Brix S, Henriksen K
We previously reported that oral delivery of salmon calcitonin (sCT) improved energy and glucose homeostasis and attenuated diabetic progression in animal models of diet-induced obesity (DIO) and type 2 diabetes, although the glucoregulatory mode of action was not fully elucidated. In the present st...
May 22, 2014
Journal:
Eur J Pharmacol
Author:
Feigh M, Andreassen KV, Gydesen S, Ottosen I, Henriksen JE, Beck-Nielsen H, Christiansen H, Karsdal MA, Henriksen K
The present study investigated a novel oral dual amylin and calcitonin receptor agonist (DACRA), KBP-042, in head-to-head comparison with salmon calcitonin (sCT) with regard to in vitro receptor pharmacology, ex vivo pancreatic islet studies, and in vivo proof of concept studies in diet-induced obes...
May 6, 2014
Journal:
Am J Physiol Endocrinol Metab
Author:
Andreassen KV, Feigh M, Hjuler ST, Gydesen S, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA, Henriksen K
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