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CONTEXT AND OBJECTIVE: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. MATERIALS AND METHODS: Five hundred and n...
December 21, 2015
Journal:
Biomarkers
Author:
Kluzek S, Bay-Jensen AC, Judge A, Karsdal MA, Shorthose M, Hart D, Newton JL, Arden NK, Spector TD
BACKGROUND:Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-telo...
July 23, 2014
Journal:
J Med Genet
Author:
Ramos YF, Metrustry S, Arden NK, Bay-Jensen AC, Beekman M, de Craen AJ, Cupples LA, Esko T, Evangelou E, Felson DT, Hart DJ, Ioannidis JP, Karsdal MA, Kloppenburg M, Lafeber F, Metspalu A, Panoutsopoulou K, Slagboom PE, Spector TD, van Spil EW, Uitterlinden AG, Zhu Y, Valdes AM, van Meurs JB, Meulenbelt I
Objective: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). Subjects and methods: Samples from 3582 individuals from the Rotterdam ...
May 22, 2014
Journal:
Osteoarthritis Cartilage
Author:
Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra SM, Hart D, Hofman A, Karsdal MA, Kloppenburg M, Kroon HM, Slagboom PE, Spector TD, Uitterlinden AG, van Meurs JB, Bay-Jensen AC, Valdes AM
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