Find an abstract and a link to most of the publications produced by Nordic Bioscience
Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es...
March 11, 2020
Journal:
Sci Rep
Author:
Rønnow S, Langholm LL, Leeming DJ, Manon-Jensen T, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Thoracius-Ussing J, Bülow Sand JM
Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and lung tissue deterioration. Given the high vascularity of the lung, von Willebrand factor (VWF), a central component of wound healing initiation, has previously been assessed in COPD. VWF processing,...
March 9, 2020
Journal:
Int J Chron Obstruct Pulmon
Author:
Langholm LL, Rønnow S, Leeming DJ, Miller BE, Vestbo J, Karsdal MA, Manon-Jensen T, Bülow Sand JM, Thal-Singer R
Background: Chronic obstructive pulmonary disease (COPD) is characterized by abnormal epithelial repair process that may result in intra-airway accumulation of fibrin. Given that plasma fibrinogen is the only FDA approved biomarker that predicts mortality and COPD exacerbations, we hypothesized that...
December 2, 2019
Journal:
Lancet Respir Med
Author:
Manon-Jensen T, Langholm LL, Karsdal MA, Vestbo J, Leeming DJ, Miller BE, Thal-Singer R, Bülow Sand JM, Rønnow S
Background: The aim of this study was to develop and validate a model for pulmonary fibrosis, using ex vivo tissue cultures of lungs from bleomycin treated animals, enabling the investigation of fibrosis remodeling using novel biomarkers for the detection of ECM protein fragments. The combination of...
July 5, 2016
Journal:
Respir Res.
Author:
Hansen NU, Karsdal MA, Brockbank S, Cruwys S, Rønnow S, Christiansen C
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