Biomarker name
Assay description
Function
ARGS
N-terminal epitope of aggrecanase mediated degradation of aggrecan
Cartilage remodeling
C3A
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C4Ma1
MMP-degradation fragment of type IVa1 collagen chain
Basement membrane degradation and remodeling
C4Ma3
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain
Basement membrane degradation
C6Ma1
Neo-epitope of MMP-2 mediated degradation of type VIa1 collagen
Connective tissue degradation
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein
Tissue inflammation
PRO-C16
C-terminal of Type XVI collagen
Intestinal matrix turnover
PRO-C3X
Cross-linked N-terminal pro-peptide of type III collagen
ECM cross-linking
PRO-C7
propeptide of type VII collagen
N/A
reC1M
Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen
Degradation of interstitial matrix and remodeling
T2CM
Neo-epitope of MMP-1 and MMP-13 mediated degradation of type II collagen
Cartilage and fibrocartilage degradation and remodeling
U-CTX-II
MMP9-or 13-degradation fragment of type II collagen
Cartilage and fibrocartilage degradation and remodeling

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