Biomarker name
Assay description
Biomarker meaning
C3M
Neo-epitope of MMP-9 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C4M
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain
Basement membrane degradation
C6M
Neo-epitope of MMP-2 mediated degradation of type VI collagen
Interface matrix degradation
PRO-C3
Released N-terminal pro-peptide of type III collagen
Fibrogenesis
PRO-C4
Internal epitope in the 7S domain of type IV collagen
Basement membrane synthesis
PRO-C5
Released C-terminal pro-peptide of type V collagen
Basement membrane degradation and remodeling

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