Cardiovascular diseases

Biomarker name
Assay description
Function
C1M
A fragment of type I collagen released by MMP
Inflammation driven degradation, ECM degradation
C3M
A fragment of type III collagen released by MMP
ECM degradation
C4M
A fragment of type IV collagen released by MMP
Basement membrane degradation, ECM degradation
CTX-III
A fragment of degraded crosslinked type III collagen
Fibrosis resolution
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen
Fibrogenesis, ECM formation
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (endotrophin)
Pro-fibrotic signaling, ECM formation
PRO-C8
A fragment of C-terminal type VIII collagen
Signaling peptide of the basement membrane, ECM formation
TUM
A fragment of type IV collagen released by MMP-2, 9
Signaling peptide of the basement membrane, ECM degradation
Canstatin
Canstatin, released NC1 domain of type IV collagen a2 chain
ECM signaling
PRO-C28
C-terminal of type XXVIII collagen
Fibrogenesis, Fibroblast activity
TIM
Neo-epitope of MMP-12 mediated degradation of titin (Cardiac isoform)
Cardiac remodeling

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