Biomarker name
Assay description
Function
ELM12
Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin
Stromal reactivity
ELM7
Neo-epitope of MMP-7 mediated degradation of elastin
EMC remodeling
ELP-3
Neo-epitope of proteinase-3 mediated degradation of elastin
Stromal reactivity
exAGNxI
Neo-epitope of aggrenase mediated aggrecan
N/A
exC2M
Neo-epitope of MMP mediated degradation of type II collagen for explant use
N/A
exFFGV
Neo-epitope of MMP mediated aggrecan
Cartilage remodeling
exPRO-C2
Released N-terminal pro-peptide of type II collagen
N/A
F1
Neo-epitope of thrombin mediated degradation of prothrombin
Thrombin activation
F1.2/F2
Neo-epitope of Fxa/Fva mediated degradation of prothrombin
Thrombin activation
FBN-C
C-terminal of fibronectin
ECM remodeling
FBN-EDA
Neo-epitope of MMP-8 mediated degradation of cellular fibronectin (EDA domain)
Stromal reactivity
FMODM
Neo-epitope of MMP-12 mediated degradation of fibromodulin
N/A
FXIIIAP
Neo-epitope of thrombin mediated degradation of transglutaminase FXIII
N/A
GDF-8
Myostatin (growth/differentiation factor 8)
N/A
HSP47-C
C-terminal of heat shock protein-47
N/A
hsPRO-C6
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
IL-6
Interleukin-6
N/A
iP3NP
Internal epitope in the N-terminal pro-peptide of type III collagen
N/A
LAM
Neo-epitope of MMP-9 mediated degradation of laminin alpha 5 chain
N/A
LG1M
Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain
Basement membrane degradation
MIM
Neo-epitope of MMP-9,12 mediated degradation of mimecan
ECM remodeling
n-BREV
N-terminal of brevican
Brain ECM remodeling
N-MID
Osteocalcin
Bone formation
NIC
Neo-epitope of cathepsin-S mediated degradation of nidogen
Basement membrane (proteoglycan) degradation
PC3X
Cross-linked N-terminal pro-peptide of type III collagen
N/A
PRO-C10
C-terminal of type X
N/A
PRO-C16
C-terminal of Type XVI collagen
Intestinal matrix turnover
PRO-C18
N-terminal type XVIII collagen
Basement membrane degradation and remodeling
PRO-C18L
N-terminal of the type XVIII collagen medium and long isoforms
Basement membrane degradation and remodeling
PRO-C20
C-terminal of type XX collagen
Interface matrix degradation
PRO-C22
C-terminal of type XXII collagen, neoepitope specific
Connective tissue formation
PRO-C23
C-terminal of type XXIII collagen
Basement membrane remodeling
PRO-C26
C-terminal of type XXVI collagen
N/A
PRO-C28
C-terminal of type XXVIII collagen
Fibrogenesis, Fibroblast activity
PRO-C3X
Cross-linked N-terminal pro-peptide of type III collagen
ECM cross-linking
PRO-C7
propeptide of type VII collagen
N/A
PRO-FIB
Neo-epitope of thrombin mediated degradation of fibrinogen
Clot formation
PROM
Neo-epitope of MMP-1 and -13 mediated degradation of prolargin
N/A
reC1M
Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen
Degradation of interstitial matrix and remodeling
Restin-1
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
Restin-2
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
sauC3M
Sandwich Assay for a 30 aa fragment of collagen type III
Degradation of interstitial matrix and remodeling
SPARC-C
C-terminal of SPARC
Stromal reactivity (binding of collagens)
SPARC-M
Neo-epitope of MMP mediated degracation of SPARC
Stromal reactivity (binding of collagens)
T-FIB
Neo-epitope of plasmin mediated degradation of fibrin
N/A
T2CM
Neo-epitope of MMP-1 and MMP-13 mediated degradation of type II collagen
Cartilage and fibrocartilage degradation and remodeling
TAU-A
Neo-epitope of ADAM-10 mediated degradation of TAU
Cognitive loss
TAU-C
Neo-epitope of caspase-3 mediated degradation of TAU
Neuronal death
TGF-beta
Neo-epitope of plasma kallikrein (PLK) cleavage of TGF-b LAP domain (L59)
Active TGF-beta
TIM
Neo-epitope of MMP-12 mediated degradation of titin (Cardiac isoform)
Cardiac remodeling

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