Biomarker name
Assay description
Biomarker for
DKK-1
Not available
Not available
EL-CG
Neo-epitope of cathepsin G mediated degradation of elastin
ECM remodeling
EL-NE (CLIA)
Neo-epitope of neutrophil elastase mediated degradation of elastin
ECM remodeling
EL-NE (Elisa)
Neo-epitope of neutrophil elastase mediated degradation of elastin
ECM remodeling
EL-NE_HP (producing)
Neo-epitope of neutrophil elastase mediated degradation of elastin
ECM remodeling
EL-SIG
Signal peptide of elastin
Not available
ELM
Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin
Stromal reactivity
ELM12
Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin
Stromal reactivity
ELM7
Neo-epitope of MMP-7 mediated degradation of elastin
EMC remodeling
ELP-3
Neo-epitope of proteinase-3 mediated degradation of elastin
Stromal reactivity
exAGNxI
Neo-epitope of aggrenase mediated aggrecan
Not available
exC2M
Neo-epitope of MMP mediated degradation of type II collagen for explant use
Not available
exFFGV
Neo-epitope of MMP mediated aggrecan
Cartilage remodeling
exPRO-C2
Released N-terminal pro-peptide of type II collagen
Not available
F1
Neo-epitope of thrombin mediated degradation of prothrombin
Thrombin activation
F1.2/F2
Neo-epitope of Fxa/Fva mediated degradation of prothrombin
Thrombin activation
FBN-C
C-terminal of fibronectin
ECM remodeling
FBN-EDA
Neo-epitope of MMP-8 mediated degradation of cellular fibronectin (EDA domain)
Stromal reactivity
FMODM
Neo-epitope of MMP-12 mediated degradation of fibromodulin
Not available
FXIIIAP
Neo-epitope of thrombin mediated degradation of transglutaminase FXIII
Not available
GDF-8
Myostatin (growth/differentiation factor 8)
Not available
HSP47-C
C-terminal of heat shock protein-47
Not available
hsPRO-C6
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
huARG
N-terminal epitope of Aggrecanase mediated degradation of aggrecan in human
Not available
huARGS
N-terminal epitope of aggrecanase mediated degradation of aggrecan in human
Cartilage remodeling
IL-6
Interleukin-6
Not available
iP3NP
Internal epitope in the N-terminal pro-peptide of type III collagen
Not available
LAM
Neo-epitope of MMP-9 mediated degradation of laminin alpha 5 chain
Not available
LG1M
Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain
Basement membrane degradation
MIM
Neo-epitope of MMP-9,12 mediated degradation of mimecan
ECM remodeling
n-BREV
N-terminal of brevican
Brain ECM remodeling
N-MID
Osteocalcin
Bone formation
NIC
Neo-epitope of cathepsin-S mediated degradation of nidogen
Basement membrane (proteoglycan) degradation
PC3X
Cross-linked N-terminal pro-peptide of type III collagen
Not available
PRO-C10
C-terminal of type X
Not available
PRO-C16
C-terminal of Type XVI collagen
Intestinal matrix turnover
PRO-C18
N-terminal type XVIII collagen
Basement membrane degradation and remodeling
PRO-C18L
N-terminal of the type XVIII collagen medium and long isoforms
Basement membrane degradation and remodeling
PRO-C2_HP
Released N-terminal pro-peptide of type II collagen
Formation of cartilage
PRO-C20
C-terminal of type XX collagen
Interface matrix degradation
PRO-C22
C-terminal of type XXII collagen, neoepitope specific
Connective tissue formation
PRO-C23
C-terminal of type XXIII collagen
Basement membrane remodeling
PRO-C26
C-terminal of type XXVI collagen
Not available
PRO-C28
C-terminal of type XXVIII collagen
Fibrogenesis, Fibroblast activity
PRO-C3_HP
Released N-terminal pro-peptide of type III collagen
Fibrogenesis
PRO-C3X
Cross-linked N-terminal pro-peptide of type III collagen
ECM cross-linking
PRO-C4_HP
Internal epitope in the 7S domain of type IV collagen
Basement membrane synthesis
PRO-C5_HP
Released C-terminal pro-peptide of type V collagen
Fibrogenesis
PRO-C6_HP
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
PRO-C7_HP
propeptide of type VII collagen
Not available

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