Biomarker name
Assay description
Biomarker for
PRO-C8
C-terminal of type VIII collagen
Vestatin
PRO-FIB
Neo-epitope of thrombin mediated degradation of fibrinogen
Clot formation
PROM
Neo-epitope of MMP-1 and -13 mediated degradation of prolargin
Not available
ratARG
N-terminal epitope of Aggrecanase mediated degradation of aggrecan in rats
Not available
reC1M
Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen
Degradation of interstitial matrix and remodeling
Restin-1
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
Restin-2
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
rPRO-C1
Internal epitope in the N-terminal pro-peptide of type I collagen
Bone formation
rPRO-C3
Released N-terminal pro-peptide of type III collagen
Not available
rPRO-C6
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
sauC3M
Sandwich Assay for a 30 aa fragment of collagen type III
Degradation of interstitial matrix and remodeling
SPARC-C
C-terminal of SPARC
Stromal reactivity (binding of collagens)
SPARC-M
Neo-epitope of MMP mediated degracation of SPARC
Stromal reactivity (binding of collagens)
T-FIB
Neo-epitope of plasmin mediated degradation of fibrin
Not available
T2CM
Neo-epitope of MMP-1 and MMP-13 mediated degradation of type II collagen
Cartilage and fibrocartilage degradation and remodeling
TAU-A
Neo-epitope of ADAM-10 mediated degradation of TAU
Cognitive loss
TAU-C
Neo-epitope of caspase-3 mediated degradation of TAU
Neuronal death
TGF-beta
Neo-epitope of plasma kallikrein (PLK) cleavage of TGF-b LAP domain (L59)
Active TGF-beta
TIM
Neo-epitope of MMP-12 mediated degradation of titin (Cardiac isoform)
Cardiac remodeling
TIM-2
Specific fragment of MMP-12-mediated degradation of titin (Muscle isoform)
Cardiac remodeling
TSP-2
N-terminal Thrombospondin 2
Not available
U-CTX-II
MMP9-or 13-degradation fragment of type II collagen
Cartilage and fibrocartilage degradation and remodeling
uC3M
Neo-epitope of MMP-9 mediated degradation of type III collagen
Not available
uC4M
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain
Not available
uPerla
Neo-epiotpe of ADAMTS mediated degradation of perlecan
ECM remodeling
VCANM
Neo-epitope of MMP-8,12 mediated degradation of versican
ECM remodeling
VICM_HP
Neo- epitope of MMP-2, 8 and trypsin mediated degradation of citrullinated vimentin
Macrophage activity
VIM
Neo-epitope of MMP-2 and MMP-8 mediated degradation of Vimentin
Not available
vWF-A
Neo-epitope of ADAMTS13 mediated degradation of von willebrand factor
von Willebrand factor activation
vWF-N
Released N-terminal pro-peptide of von willebrand factor
von Willebrand factor activation
X-FIB
Neo-epitope of plasmin mediated degradation of cross-linked fibrin (sandwich assay)
Clot resolution

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