A fragment of the internal 7S domain of type IV collagen
Liver fibrosis accumulation is considered a turnover disease, with formation exceeding degradation Remodelling of extracellular matrix is crucial in progressive liver fibrosis. The role of basement membrane collagen type IV in advanced cirrhosis and acute decompensation may be an indicator of outcome.
Patients with decompensated cirrhosis from the prospective NEPTUN cohort (ClinicalTrials.gov Identifier: NCT03628807), who underwent transjugular intrahepatic portosystemic shunt procedure were included. Clinical and laboratory parameters, PRO-C4 and C4M levels were measured in blood samples from portal and hepatic veins just before transjugular intrahepatic portosystemic shunt placement.
Levels of C4M and PRO-C4 are significantly lower in patients with massive ascites and impaired renal sodium excretion. C4M and PRO-C4 show gender-specific profiles with significantly lower levels in females compared to males.
Therapeutic area
Gastroenterology, Cancer, Hepatic diseases, Respiratory diseases, Dermatology, Rheumatology
Biomarker panels
Lung Epithelial Damage & Thrombosis, HepNIT Panel™: Hepatic Non-invasive Tests, Liver Fibrosis Outcome, Pericellular Fibrosis Remodeling, Tissue Fibrosis, Angiogenesis / Epithelial Damage / Basement Membrane, Tissue Fibrosis
Function
Basement membrane synthesis, ECM formation
Alternative names
P4NP7S, PROC4
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