Respiratory System
1. Aug 2016
Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
RATIONALE:
Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal of all fibrotic conditions with no curative therapies. Common pathomechanisms between IPF and cancer are increasingly recognised, including dysfunctional pan-PI3 kinase (PI3K) signalling as a driver of aberran…
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Journal:
Authors:
- Mercer PF,
- Woodcock HV,
- Eley JD,
- Platé M,
- Sulikowski MG,
- Durrenberger PF,
- Franklin L,
- Nanthakumar CB,
- Man Y2,
- Genovese F,
- McAnulty RJ,
- Yang S,
- Maher TM,
- Nicholson AG,
- Arbit E,
- Marshall RP,
- Lukey PT,
- Chambers RC,