Collagen turnover profiles in chronic kidney disease.
Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance between formation and degradation of extracellular matrix proteins. We investigated the collagen turnover profile of 81 non-dialysis CKD stage 2-5 patients by measuring peptides reflecting formation and degradation o…
Journal:
Authors:
- Rasmussen DG,
- Boesby L,
- Nielsen SH,
- Teepel M,
- Birot S,
- Karsdal MA,
- Kamper Al,
- Genovese F,
Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.
Following liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were…
Journal:
Authors:
- Nielsen MJ,
- Villesen IF,
- Gudmann NS,
- Leeming DJ,
- Krag A,
- Karsdal MA,
- Zimmermann T,
- Schuppan D,
Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis.
Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from the disease-affected tissue. We investigated whether collagen metabolites were associated with disease activity and could distinguish non-radiographic(nr)-axSpA from ankylosing spondylitis (AS). A…
Journal:
Authors:
- Husakova M,
- Bay-Jensen AC,
- forejtová S,
- Zegzulkova K,
- Tomcik M,
- gregová M,
- Bubová K,
- Horínková J,
- Gatterová J,
- Pavelka K,
- Siebuhr AS,
Cancer risk in relation to body fat distribution, evaluated by DXA-scans, in postmenopausal women - the Prospective Epidemiological Risk Factor (PERF) study
Studies with direct measures of body fat distribution are required to explore the association between central and general obesity to cancer risk in postmenopausal women. This study investigates the association between central obesity and general obesity to overall/site-specific cancer risk in postme…
Journal:
Authors:
- Stanstrup LM,
- Nielsen HB,
- Pedersen BK,
- Karsdal MA,
- Blair JPM,
- Christensen JF,
- Bager CL,
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort
Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es…
Journal:
Authors:
- Ronnow SR,
- Langholm LL,
- Sand JMB,
- Thoracius-Ussing J,
- Leeming DJ,
- Manon-Jensen T,
- Tal-Singer R,
- Miller BE,
- Karsdal MA,
- Vestbo J,
GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro
C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to have any clinical utility to date. Here, we describe…
Journal:
Authors:
- Löfvall H,
- Katri A,
- Dabrowska A,
- Karsdal MA,
- Luo Y,
- He Y,
- Manon-Jensen T,
- Dziegiel MH,
- Bay-Jensen AC,
- Thudium CS,
- Henriksen K,
Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation …
Journal:
Authors:
- Luetkens JA,
- Wolpers AC,
- Beiert T,
- Kuetting D,
- Dabir D,
- Homsi R,
- Meemdermann H,
- Day'e NA,
- Knappe V,
- Karsdal MA,
- Nielsen SH,
- Genovese F,
- Stöckjgt F,
- Linhart M,
- Thomas D,
- Nickenig G,
- Schild HH,
- Schrickel JW,
- Andrié RP,
Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r…
Journal:
Authors:
- Bertelsen DM,
- Neergaard JS,
- Bager CL,
- Nielsen SH,
- Secher NH,
- Svendsen JH,
- Bihlet AR,
- Andersen JR,
- Karsdal MA,
- Christiansen C,
- Nielsen HB,
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as cathepsins (Cts) regulate this process in other organs, however, their role in CKD is still unknown. Here we describe a novel role for catheps…
Journal:
Authors:
- Fox C,
- Cocchiaro P,
- Oakley F,
- Howarth R,
- Callaghan K,
- Leslie J,
- Luli S,
- Wood KM,
- Sheerin NS,
- Genovese F,
- Moles A,