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Systemic Sclerosis, Rheumatology, Extracellular Matrix Research
28. Apr 2020

Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - A Longitudinal Study

Tissue turnover, especially in the skin, is altered in systemic sclerosis (SSc), leading to tissue accumulation. The objective was to examine type III, IV, and VI collagens turnovers in SSc and investigate longitudinal alterations in relation to modified Rodnan Skin Score (mRSS). We included patient…

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Rheumatology, Osteoarthritis, Extracellular Matrix Research
7. Apr 2020

Sprifermin (rhFGF18) Versus Vehicle Induces a Biphasic Process of Extracellular Matrix Remodeling in Human Knee OA Articular Cartilage Ex Vivo

Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We hypothesized that a temporal multiphasic process of extracellular matrix (ECM) degradation and formation underlie this effect. We aimed to characteriz…

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Gastrointestinal, Extracellular Matrix Research
3. Apr 2020

A Fragment of Collagen Type VI alpha-3 Chain Is Elevated in Serum From Patients With Gastrointestinal Disorders

Extracellular matrix (ECM) remodeling is a hallmark of the pathology of gastrointestinal disorders. Collagen type VI (COL6) is produced by fibroblasts, and the COL6 α3-chain has shown to be elevated in patients with ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC). Measuring…

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Cardiovascular System
17. Jan 2020

Atrial fibrillation is associated with lean body mass in postmenopausal women.

This study investigated the association between body composition and risk of atrial fibrillation (AF) in postmenopausal women. In a retrospective analysis we assessed data from 5704 postmenopausal women (age 70.7 ± 6.5 yrs.) who in 1999-2001 participated in The Prospective Epidemiological Risk Facto…

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Extracellular Matrix Research, Pancreas
24. Dec 2019

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular …

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Authors:

  • Willumsen N,
  • Ali SM,
  • Leitzel K,
  • Drabick JJ,
  • Yee N,
  • Polimera HV,
  • Nagabhairu V,
  • Krecko L,
  • Ali A,
  • Maddukuri A,
  • Moku P,
  • Poullose J,
  • Menon H,
  • Pancholy N,
  • Costa L,
  • Karsdal MA,
  • Lipton A,
Renal System, Chronic Renal Disease, Extracellular Matrix Research, Biomarker position
5. Nov 2019

Collagen turnover profiles in chronic kidney disease.

Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance between formation and degradation of extracellular matrix proteins. We investigated the collagen turnover profile of 81 non-dialysis CKD stage 2-5 patients by measuring peptides reflecting formation and degradation o…

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Hepatic System, Biomarker position
16. Oct 2019

Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.

Following liver transplantation (LT), 10-30% of patients develop recurrent cirrhosis (RC). There is an urgent need for predictive non-invasive markers for improved monitoring of these patients. Here we studied extracellular matrix biomarkers as predictors of RC after LT. Forty-seven LT patients were…

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Rheumatology, Spondyloarthropathies, Biomarker position
2. Aug 2019

Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis.

Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from the disease-affected tissue. We investigated whether collagen metabolites were associated with disease activity and could distinguish non-radiographic(nr)-axSpA from ankylosing spondylitis (AS). A…

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Authors:

  • Husakova M,
  • Bay-Jensen AC,
  • forejtová S,
  • Zegzulkova K,
  • Tomcik M,
  • gregová M,
  • Bubová K,
  • Horínková J,
  • Gatterová J,
  • Pavelka K,
  • Siebuhr AS,
29. Mar 2019

Cancer risk in relation to body fat distribution, evaluated by DXA-scans, in postmenopausal women - the Prospective Epidemiological Risk Factor (PERF) study

Studies with direct measures of body fat distribution are required to explore the association between central and general obesity to cancer risk in postmenopausal women. This study investigates the association between central obesity and general obesity to overall/site-specific cancer risk in postme…

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Respiratory System, Chronic Obstructive Pulmonary Disease
9. Mar 2019

Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort

Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es…

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Rheumatology, Bone
28. Feb 2019

GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to have any clinical utility to date. Here, we describe…

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Cardiovascular System
11. Sep 2018

Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy

To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation …

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Authors:

  • Luetkens JA,
  • Wolpers AC,
  • Beiert T,
  • Kuetting D,
  • Dabir D,
  • Homsi R,
  • Meemdermann H,
  • Day'e NA,
  • Knappe V,
  • Karsdal MA,
  • Nielsen SH,
  • Genovese F,
  • Stöckjgt F,
  • Linhart M,
  • Thomas D,
  • Nickenig G,
  • Schild HH,
  • Schrickel JW,
  • Andrié RP,
Extracellular Matrix Research
29. Mar 2018

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r…

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Renal System
1. Feb 2016

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as cathepsins (Cts) regulate this process in other organs, however, their role in CKD is still unknown. Here we describe a novel role for catheps…

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Authors:

  • Fox C,
  • Cocchiaro P,
  • Oakley F,
  • Howarth R,
  • Callaghan K,
  • Leslie J,
  • Luli S,
  • Wood KM,
  • Sheerin NS,
  • Genovese F,
  • Moles A,