Cardiovascular System
11. Sep 2018
Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation …
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Journal:
Authors:
- Luetkens JA,
- Wolpers AC,
- Beiert T,
- Kuetting D,
- Dabir D,
- Homsi R,
- Meemdermann H,
- Day'e NA,
- Knappe V,
- Karsdal MA,
- Nielsen SH,
- Genovese F,
- Stöckjgt F,
- Linhart M,
- Thomas D,
- Nickenig G,
- Schild HH,
- Schrickel JW,
- Andrié RP,
Extracellular Matrix Research
29. Mar 2018
Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r…
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Journal:
Authors:
- Bertelsen DM,
- Neergaard JS,
- Bager CL,
- Nielsen SH,
- Secher NH,
- Svendsen JH,
- Bihlet AR,
- Andersen JR,
- Karsdal MA,
- Christiansen C,
- Nielsen HB,
Renal System
1. Feb 2016
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as cathepsins (Cts) regulate this process in other organs, however, their role in CKD is still unknown. Here we describe a novel role for catheps…
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Journal:
Authors:
- Fox C,
- Cocchiaro P,
- Oakley F,
- Howarth R,
- Callaghan K,
- Leslie J,
- Luli S,
- Wood KM,
- Sheerin NS,
- Genovese F,
- Moles A,