A non-invasive biomarker of type III collagen degradation reflects ischaemia reperfusion injury in rats.
Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace…
Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases
The extent of renal fibrosis in chronic kidney disease (CKD) is the best predictor for progression of most renal diseases. To date, no established biomarkers of renal fibrosis exist.
We measured circulating and urinary-specific matrix metalloproteinase (MMP)-generated colla…