Extracellular Matrix Research, Hepatic System, Non-Alcoholic Fatty Liver Disease
9. Apr 2020
Collagen Biology and Non-Invasive Biomarkers of Liver Fibrosis
There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liv…
Read the publication
Journal:
Authors:
- Karsdal MA,
- Daniels SJ,
- Nielsen SH,
- Bager C,
- Rasmussen DGK,
- Loomba R,
- Surabattula R,
- Villesen IF,
- Luo Y,
- Shevell D,
- Gudmann NS,
- Nielsen MJ,
- George J,
- Christian R,
- Leeming DJ,
- Schuppan D,
Hepatic System, Extracellular Matrix Research, Renal System
9. Feb 2019
Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis
BACKGROUND & AIMS:
Remodelling of extracellular matrix is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. Extratracellular matrix is compiled of deposition of various components. The role of basement membrane collagen type IV in advanced …
Read the publication
Journal:
Authors:
- Lehmann J,
- Praktiknjo M,
- Nielsen MJ,
- Schierwagen R,
- Meyer C,
- Thomas D,
- Violi F,
- Strassburg CP,
- Bendtsen F,
- Møller S,
- Krag A,
- Karsdal M,
- Leeming DJ,
- Trebicka J,
Extracellular Matrix Research, Hepatitis B/C, Hepatic System
1. Feb 2015
Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C
BACKGROUND & AIMS:
Fibrogenesis results in release of certain extracellular matrix protein fragments into the circulation. We evaluated the diagnostic and prognostic performance of two novel serological markers, the precisely cleaved N-terminal propeptide of type III collagen (Pro-C3) and a peptide…
Read the publication
Journal:
Authors:
- Nielsen MJ,
- Veidal SS,
- Karsdal MA,
- Leeming DJ,
- Vainer B,
- Gardner SD,
- Hamatake R,
- Goodman ZD,
- Schuppan D,
- Patel K,
Hepatic System, Alcoholic Liver Disease
3. Mar 2013
Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis--a serological evaluation
BACKGROUND/AIM:
We investigated nine novel biomarkers of extracellular matrix (ECM) remodelling in a rat model of liver fibrosis.
METHODS:
Liver fibrosis was induced in 52 male Wistar rats by inhalation of carbon tetrachloride and the level of hepatic fibrosis was assessed by Sirius red stainin…
Read the publication
Journal:
Authors:
- Leeming DJ,
- Byrjalsen I,
- Jiménez W,
- Christiansen C,
- Karsdal MA,
Hepatic System, Non-Alcoholic Fatty Liver Disease
30. Oct 2010
Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis
BACKGROUND:
During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via …
Read the publication
Journal:
Authors:
- Veidal SS,
- Vassiliadis E,
- Barascuk N,
- Zhang C,
- Segovia-Silvestre T,
- Klickstein L,
- Larsen MR,
- Qvist P,
- Christiansen C,
- Vainer B,
- Karsdal MA,