Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.
Extracellular matrix metabolism and cardiac cell death participate centrally in myocardial infarction (MI). This study tested the roles of collagenolytic cathepsin K (CatK) in post-MI left ventricular remodeling.
METHODS AND RESULTS:
Patients with acute MI had higher plasma CatK lev…