Alzheimer’s Disease, Central Nervous System
11. May 2015
The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's disease
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early intervention. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the differential diagnosis. Identifying biomarkers…
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Authors:
- Inekci D,
- Jonesco DS,
- Kennard S,
- Karsdal MA,
- Henriksen K,
Bone
23. Mar 2004
Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability
Osteoblasts undergo apoptosis or differentiate into either osteocytes or bone-lining cells after termination of bone matrix synthesis. In this study, we investigated the role of matrix metalloproteinases (MMPs) in differentiation of osteoblasts, bone formation, transdifferentiation into osteocytes, …
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Journal:
Authors:
- Karsdal MA,
- Andersen TA,
- Bonewald L,
- Christiansen C,