Extracellular Matrix Research, Renal System
22. May 2016
Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis
The aim of this study was to set up an ex vivo model for renal interstitial fibrosis in order to investigate the extracellular matrix (ECM) turnover profile in the fibrotic kidney. We induced kidney fibrosis in fourteen 12-week-old male Sprague Dawley rats by unilateral ureteral obstruction (UUO) su…
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Journal:
Authors:
- Genovese F,
- Kàrpàti ZS,
- Nielsen SH,
- Karsdal MA,
Respiratory System, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
11. Jul 2012
Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis
In both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), abnormally high collagen remodeling occurs within the lung tissue. Matrix metalloproteinase (MMP)-degraded type I, III, IV, V and VI collagen and a disintegrin and metalloproteinase with thrombospondin moti…
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Journal:
Authors:
- Leeming DJ,
- Sand JM,
- Nielsen MJ,
- Genovese F,
- Martinez FJ,
- Hogaboam CM,
- Han MK,
- Klickstein LB,
- Karsdal MA,
Hepatic System, Alcoholic Liver Disease
7. Jun 2012
Circulating levels of a collagen type v propeptide fragment in a carbon tetrachloride reversible model of liver fibrosis
AIM:
To measure levels of the collagen V formation marker CO5-1230 during liver fibrosis progression and regression.
METHODS:
Monoclonal antibodies were raised against the sequence TAALGDIMGH located at the start of the C-terminal propeptide between amino acid position 1230' and 1239' (CO5-1230…
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Journal:
Authors:
- Vassiliadis E,
- Veidal SS,
- Hansen C,
- Karsdal MA,
- Leeming DJ,
Cardiovascular System, Atherosclerosis
10. May 2012
Novel cardiac-specific biomarkers and the cardiovascular continuum
The concept of the cardiovascular continuum, introduced during the early 1990s, created a holistic view of the chain of events connecting cardiovascular-related risk factors with the progressive development of pathological-related tissue remodelling and ultimately, heart failure and death. Understan…
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Journal:
Authors:
- Vassiliadis E,
- Barascuk N,
- Didangelos A,
- Karsdal MA,
Hepatic System, Extracellular Matrix Research
3. Jan 2012
Molecular serum markers of liver fibrosis
Fibrosis is a hallmark histologic event of chronic liver diseases and is characterized by the excessive accumulation and reorganization of the extracellular matrix (ECM). The gold standard for assessment of fibrosis is liver biopsy. As this procedure has various limitations, including risk of patien…
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Journal:
Authors:
- Liu T,
- Wang X,
- Karsdal MA,
- Leeming DJ,
- Genovese F,
Cardiovascular System, Atherosclerosis
11. Jun 2011
Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice
AIM:
Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (ELI…
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Journal:
Authors:
- Barascuk N,
- Vassiliadis E,
- Zheng Q,
- Wang Y,
- Wang W,
- Larsen L,
- Rasmussen LM,
- Karsdal MA,
Hepatic System, Alcoholic Liver Disease
24. Mar 2011
Measurement of CO3-610, a potential liver biomarker derived from matrix metalloproteinase-9 degradation of collagen type III, in a rat model of reversible carbon-tetrachloride-induced fibrosis
BACKGROUND AND AIM:
The current study utilized a carbon tetrachloride (CCl(4))-induced liver fibrosis model to measure levels of the MMP9-mediated collagen type III degradation fragment CO3-610 (site of cleavage: KNGETGPQGP), during disease progression and regression, and to investigate a potential…
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Journal:
Authors:
- Vassiliadis E,
- Larsen DV,
- Clausen RE,
- Veidal SS,
- Barascuk N,
- Larsen L,
- Simonsen H,
- Silvestre TS,
- Hansen C,
- Overgaard T,
- Leeming DJ,
- Karsdal MA,