Chronic Obstructive Pulmonary Disease, Respiratory System
10. Sep 2018
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is characterized by high levels of protease activity leading to degradation of elastin followed by loss of elasticity of the lung and the development of emphysema. Elastin is an essential structural component of the lung parenchyma to support the expansio…
Read the publication
Journal:
Authors:
- Gudmann NS,
- Manon-Jensen T,
- Sand JMB,
- Diefenbach C,
- Sun S,
- Danielsen A,
- Karsdal MA,
- Leeming DJ,
Extracellular Matrix Research
27. Jul 2016
Quantification of fibronectin as a method to assess ex vivo extracellular matrix remodeling
Altered architecture, composition and quality of the extracellular matrix (ECM) are pathological hallmarks of several inflammatory and fibro-proliferative pathological processes such as osteoarthritis (OA), rheumatoid arthritis (RA), fibrosis and cancer. One of the most important components of the E…
Read the publication
Journal:
Authors:
- Bager CL,
- Gudmann NS,
- Willumsen N,
- Leeming DJ,
- Karsdal MA,
- Bay-Jensen AC,
- Høgdall E,
- Balslev I,
- He Y,
Bone
23. Jan 2009
Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7
The chloride-proton antiporter ClC-7 has been speculated to be involved in acidification of the lysosomes and the resorption lacunae in osteoclasts; however, neither direct measurements of chloride transport nor acidification have been performed. Human osteoclasts harboring a dominant negative mutat…
Read the publication
Journal:
Authors:
- Henriksen K,
- Gram J,
- Neutzsky-Wulff AV,
- Jensen VK,
- Dziegiel MH,
- Bollerslev J,
- Karsdal MA,
Bone
8. Feb 2008
Osteoclasts secrete non-bone derived signals that induce bone formation
Bone turnover is a highly regulated process, where bone resorption in the normal healthy individual always is followed by bone formation in a manner referred to as coupling. Patients with osteopetrosis caused by defective acidification of the resorption lacuna have severely decreased resorption, in …
Read the publication
Journal:
Authors:
- Karsdal MA,
- Neutzsky-Wulff AV,
- Dziegiel MH,
- Christiansen C,
- Karsdal M,
Bone
7. Sep 2007
Dissolution of the inorganic phase of bone leading to release of calcium regulates osteoclast survival
Osteoclasts are the sole cells possessing the ability to resorb calcified bone matrix. This occurs via secretion of hydrochloric acid mediated by the V-ATPase and the chloride channel ClC-7. Loss of acidification leads to osteopetrosis characterized by ablation of bone resorption and increased osteo…
Read the publication
Journal:
Authors:
- Nielsen RH,
- Karsdal MA,
- Sørensen MG,
- Dziegiel MH,
- Henriksen K,