7 Publication(s) found
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Renal System, Chronic Renal Disease
11. Dec 2017

Urinary endotrophin predicts disease progression in patients with chronic kidney disease

Renal fibrosis is the central pathogenic process in progression of chronic kidney disease (CKD). Collagen type VI (COL VI) is upregulated in renal fibrosis. Endotrophin is released from COL VI and promotes pleiotropic pro-fibrotic effects. Kidney disease severity varies considerably and accurate inf…

Renal System, Chronic Renal Disease
21. Apr 2017

Non-invasive quantification of collagen turnover in renal transplant recipients

Kidney allograft failure due to chronic injury/rejection remains the main cause of graft loss in renal transplant recipients (RTR). Here, we investigated whether specific biomarkers of extracellular matrix (ECM) turnover are associated with allograft function and chronic kidney disease (CKD) stage i…

Chronic Renal Disease, Renal System
12. Apr 2017

Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease

BACKGROUND:
Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. The underlying pathophysiological processes are not entirely understood but may include dysregulation of extracellular matrix formation with accelerated systemic and r…

Chronic Renal Disease
20. Mar 2017

Urinary collagen degradation products as early markers of progressive renal fibrosis

BACKGROUND:
Renal fibrogenesis is associated with increased ECM remodeling and release of collagen fragments in urine in progressive renal disease. We investigated the diagnostic value of urinary collagen degradation products in a proteinuria-driven fibrosis rat model with and without anti-fibrotic…

Renal System, Chronic Renal Disease
1. Jul 2015

Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases

BACKGROUND:
The extent of renal fibrosis in chronic kidney disease (CKD) is the best predictor for progression of most renal diseases. To date, no established biomarkers of renal fibrosis exist.

METHODS:
We measured circulating and urinary-specific matrix metalloproteinase (MMP)-generated colla…

Extracellular Matrix Research, Renal System, Chronic Renal Disease
26. Apr 2015

Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy

BACKGROUND:
Renal fibrosis is the hallmark of progression to end-stage kidney disease. Non-invasive biomarkers of renal fibrosis could serve as specific end points in clinical trials and improve monitoring and stratification of patients with chronic kidney disease (CKD). To address this, we measure…

Renal System, Chronic Renal Disease
22. Aug 2013

Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis

OBJECTIVE:
The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

METHODS:
We perfor…