Industrial PhD project: Endotyping of Spondyloarthritis patients 

We have an open position for a 3-year industrial PhD fellowship. The position is a collaboration between Nordic Bioscience and University of Copenhagen. The position is based at Nordic Bioscience in Herlev, Denmark, and will be conducted with enrollment at University of Copenhagen in Copenhagen, Denmark.  

The project is funded by Innovation fund Denmark. 

Project title: Endotyping of spondyloarthritis patients: Understanding extracellular matrix remodeling in axial spondyloarthritis and the association with disease activity and severity 

The project objectives are: 

  1. To test blood-based markers of ankylosis, fibrosis and chronic inflammation clinical trials to find association between tissue profiles and clinical measures of disease activity and severity in cohorts of axial spondyloarthritis.
  2. To combine biomarker data with clinical measures to generate endotypes (clusters) that may identify and characterize axial spondyloarthritis phenotypes. 
  3. To explore, identify and develop novel markers of extracellular matrix (ECM) remodeling relevant for the pathogenesis of axial spondyloarthritis 

 You will play a pivotal role in identifying new axial spondyloarthritis endotypes using a combination of blood-based markers and commonly used clinical assessments methodologies by providing novel insight into tissue remodeling and disease pathogenesis for the benefit of the patients. 

Nordic Bioscience: 

Nordic Bioscience is a Danish biotech company located just outside Copenhagen. Nordic Bioscience has app. 200 employees with the majority being involved in science. The focus is understanding of the extracellular matrix and we are specialized in precision medicine using unique biomarker technologies. We are organized in several research teams with focus on a variety of diseases ranging from arthritis through fibrosis to type 2 diabetes and obesity. Our approach is highly scientific, and we take pride in frequently publishing our results in leading journals worldwide resulting in publication of around 50 articles each year. 

This PhD position is within the Biomarkers and Research Division of Nordic Bioscience and based in the ImmunoScience Group, where they focus on biomarker development and utilization in patients with various inflammatory diseases.  

Supervision: 

The supervisors will be Signe Holm Nielsen, email: shn@nordicbio.com, Anne-Christine Bay-Jensen (Nordic Bioscience), Mikkel Østergaard (University of Copenhagen) and Susanne Juhl Pedersen (Rigshospitalet). 

 Required qualifications: 

The successful candidate must hold a relevant MSc degree (biochemistry, biomedicine, biotechnology, pharmaceutical science or alike), have a weighted grade average of 8.2 with at least grade 10 in MSc thesis. Fluency in English is essential, as well as being able to work as a part of a research team. Knowledge of basic statistics and analysis of clinical studies is an advantage. 

General job description: 

Your key tasks as a PhD fellow are to:  

  • Develop, optimize, and validate enzyme-linked immunosorbent assays (ELISAs) targeting proteins known to be involved in spondyloarthritis 
  • Manage and carry through your research project  
  • Take PhD courses  
  • Write scientific articles and your PhD thesis  
  • Participate in national and international congresses and scientific meetings  
  • Disseminate your research  

Key criteria for the assessment of applicants: 

  • The grades achieved during bachelor/master studies  
  • Relevant skills and knowledge 
  • Previous publications 
  • Language skills  
  • Relevant work experience 
  • Other professional activities  
  • Assessment of the candidate’s motivation letter 

Terms of employment: 

The position as industrial PhD fellow is available for a 3-year period. 

The terms of employment and salary are in accordance with the local and national rules and in accordance to the rules and regulations laid down by the Innovation fund Denmark. Exact salary will be confirmed upon appointment. 

Nordic Bioscience is offering: 

  • An important role in a highly dynamic research organization with world-wide reach 
  • An environment driven by science and good ideas, where you can truly make a difference and see your own ideas come to life 
  • Great opportunities for personal development 
  • Contribution to our academic publication activities 
  • A flat, tight organization in which you can impact the project success  

How to apply:  

Applicants are requested to submit their application to Signe Holm Nielsen, shn@nordicbio.com including (in word or pdf):  

  • Cover letter: Letter stating the interest in and qualifications for the project (max. one page).  
  • Full CV. 
  • List of publications. 
  • Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used. 
  • For those applicants whose principal language of instruction during their BSc/MSc was not English it will be an advantage if they enclose IELTS or TOEFL test scores or equivalent proof of English skills.  

For further information, applicants may contact Signe Holm Nielsen, email: shn@nordicbio.com 

Deadline for application is August 102020.