Figure 2. Biomarkers of SSc progression
A balanced extracellular matrix (ECM) is necessary to preserve organ integrity and tissue homeostasis.
In SSc, as shown in Figure 2, this balance is altered, and the fibrosis biomarkers (PRO-C3 and PRO-C6) are associated with disease progression (10% decline in FVC%, or increased mRSS >25% during a one-year clinical follow-up).
At the same time, tissue degradation biomarkers were associated with stable disease.
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