A balanced extracellular matrix (ECM) is necessary to preserve skin integrity and tissue homeostasis. Several ECM components of the dermis, epidermis, and epidermal basement membrane, reflecting the individual skin compartments are remodeled during hidradenitis suppurativa progression. Biomarkers related to disease severity and activity in hidradenitis suppurativa are crucial for use in clinical trials, but also to advance the knowledge of the biological complexity behind hidradenitis suppurativa.
The biomarkers utility in disease severity (Hurley staging) and disease activity (Satorious Score, HSS) are depicted by C1M (Dermis degradation; MMP-degraded type I collagen) and CPa9-HNE (Neutrophil acitivity; S100A9 degraded by human neutrophil elastase), in Figure 1. Both biomarkers are associated with disease severity and activity.
Figure 1. The C1M and CPa9-HNE biomarkers are associated with disease severity and activity
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