A world without kidney diseases
The world's premier nephrology meeting hosted by the American Society of Nephrology
Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has more than 21,000 members representing 131 countries.
Our Renal and Cardiovascular Research team, Federica Genovese, Alexandra Louise Møller and Daniel G. K. Rasmussen, will be presenting two posters at the upcoming ASN Kidney Week.
Biomarkers reflecting extracellular matrix turnover are prognostic for kidney function decline in patients with ADPKD
Here we show that biomarkers of collagen remodeling measured in urine and circulation at baseline are associated with the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease.
Our urinary biomarker of collagen type VI formation, PRO-C6, can identify patients at risk of rapid decline in kidney function as early as 3 months after measurement - something that cannot be detected by looking only at which kidney function the patient is starting from.
We believe it is time to put kidney fibrosis more in the center - even in diseases where other aspects (such as kidney volume) are the focus of attention.
The Extracellular Matrix Signaling Molecule Endoptrophin is Associated with Diabetic Complications in Type 1 Diabetes
We are presenting exciting preliminary data on Diabetic Kidney Disease #DKD using Nordic Bioscience’s biomarker PRO-C6. PRO-C6 quantifies collagen type VI formation and levels of the signaling molecule endotrophin.
Currently, tools are needed to predict diabetic complications before clinical manifestations to develop the concept of precision medicine.
We demonstrate that endotrophin is associated with diabetic complications in type 1 diabetes. These findings may indicate that endotrophin identifies diabetic patients with active fibrogenesis and tissue damage.
The posters are available on-demand from 10:00 a.m. PDT, Nov. 4.