Nordic Bioscience has a unique portfolio of more than 70 biomarkers that are available for analyzing samples in our College of American Pathology certified laboratory.

Looking for a biomarker, which is not on the list? Request a proposal for customized development.

Nordic Bioscience FingerprintTM Technology - Assay Portfolio

Biomarker Specification Measure Conserved in Note Reference
Biomarker
PRO-C1
Specification
Internal epitope in the N-terminal pro-peptide of type I collagen
Measure
ECM remodeling: Collagen formation
Conserved in
Human, rat
Note
serum, plasma 50 µl
Reference
(1)
Biomarker
PRO-C2
Specification
Released N-terminal pro-peptide of type II collagen
Measure
Cartilage remodeling: Collagen formation
Conserved in
Human
Note
serum. 50 µl
Reference
(2)
Biomarker
PRO-C3
Specification
Released N-terminal pro-peptide of type III collagen
Measure
ECM remodeling: Collagen formation
Conserved in
Human, rat, mouse
Note
serum, plasma, urine. 50 µl
Reference
(3)
Biomarker
PRO-C3X
Specification
Cross-linked N-terminal pro-peptide of type III collagen
Measure
ECM cross-linking
Conserved in
Human
Note
serum. 50 µl
Biomarker
iP3NP
Specification
Internal epitope in the N-terminal pro-peptide of type III collagen
Measure
ECM remodeling: Collagen formation
Conserved in
Human, rat
Note
urine. 50 µl
Biomarker
PRO-C4
Specification
Internal epitope in the 7S domain of type IV collagen
Measure
ECM remodeling: Basement membrane turnover
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(4)
Biomarker
PRO-C5
Specification
Released C-terminal pro-peptide of type V collagen
Measure
ECM remodeling: Collagen formation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(5;6)
Biomarker
PRO-C6
Specification
C-terminal of released C5 domainof type VI collagen α3 chain (endotrophin)
Measure
ECM remodeling: Collagen formation
Conserved in
Human
Note
serum, plasma, urine. 50 µl
Reference
(7)
Biomarker
PRO-C8
Specification
C-terminal of type VIII collagen
Measure
ECM remodeling: Collagen turnover
Conserved in
Human, rat
Note
serum, plasma. 50µl
Reference
(47)
Biomarker
PRO-C10
Specification
C-terminal of type X
Measure
Cartilage remodeling: Chondrocyte hypertrophy
Conserved in
Human
Note
serum. 50µl
Biomarker
PRO-C11
Specification
Released N-terminal pro-peptide of type XI collagen
Measure
ECM remodeling: Collagen formation
Conserved in
Human
Note
serum. 50µl
Biomarker
PRO-C16
Specification
C terminal of Type XVI collagen
Measure
ECM remodeling: Collagen turnover
Conserved in
Human
Note
serum. 50µl
Reference
(48)
Biomarker
PRO-C18
Specification
N-terminal type XVIII collagen
Measure
Vascular remodeling
Conserved in
Human
Note
serum, plasma. 50µl
Biomarker
PRO-C23
Specification
C-terminal of ype XXIII collagen
Measure
Epithelial and ECM remodeling: Epithelial damage basement membrane remodeling
Conserved in
Human, rat
Note
serum, plasma. 50µl
Biomarker Specification Measure Conserved in Note Reference
Biomarker
C1M
Specification
Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen
Measure
ECM remodelling: Collagen degradation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(8;9)
Biomarker
alphaC2M
Specification
Neo-epitope of MMP-mediated degradation of type II collagen
Measure
Young cartilage degradation: Collagen degradation
Conserved in
Human, mouse, rat,
Note
serum, plasma. 80 µl
Reference
(10)
Biomarker
betaC2M
Specification
Neo-epitope of MMP-mediated degradation of isomerized type II collagen
Measure
Old cartilage degradation: Collagen degradation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
In submission
Biomarker
C3M
Specification
Neo-epitope of MMP-9 mediated degradation of type III collagen
Measure
ECM remodelling: Collagen degradation
Conserved in
Human, mouse, rat
Note
serum, plasma, urine. 50 µl
Reference
(11;12)
Biomarker
SauC3M
Specification
Sandwich Assay for a 30 aa fragment of collagen type III
Measure
ECM remodeling: Collagen degradation
Conserved in
Human
Note
urine. 50 µl
Biomarker
C3A
Specification
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Measure
ECM remodeling: Collagen degradation
Conserved in
Human, rat
Note
serum, plasma. 50 µl
Reference
(46)
Biomarker
C3C
Specification
Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen
Measure
ECM remodeling: Collagen degradation
Conserved in
Human
Note
serum, plasma, urine. 50 µl
Biomarker
C4M
Specification
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain
Measure
ECM remodelling: Basement membrane degradation
Conserved in
Human, mouse, rat
Note
serum, plasma, urine. 50µl
Reference
(13)
Biomarker
C4Ma3
Specification
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain
Measure
ECM remodelling: Basement membrane degradation
Conserved in
Human, rat
Note
serum, 50 µl
Reference
(13)
Biomarker
C5M
Specification
Neo-epitope of MMP-2,9 mediated degradation of type V collagen
Measure
ECM remodelling: Collagen degradation
Conserved in
Human
Note
serum, plasma. 50 µl
Reference
(14)
Biomarker
C6M
Specification
Neo-epitope of MMP-2 mediated degradation of type VI collagen
Measure
ECM remodelling: Collagen degradation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50µl
Reference
(15;16)
Biomarker
C6Ma3
Specification
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Measure
ECM remodeling: Collagen degradation
Conserved in
Human
Note
serum. 50 µl
Biomarker
C7M
Specification
Neo-epitope of type MMP-13 mediated decradation of type VII collagen
Measure
ECM remodelling: Collagen degradation
Conserved in
Human
Note
serum. 50µl
Biomarker
C10C
Specification
Neo Epitope of cathepsin-K mediated decradation of type X collagen
Measure
ECM remodelling: Chondrocyte hypertrophy
Conserved in
Human
Note
Reference
(17)
Biomarker
TUM
Specification
Tumstatin, a MMP-9 mediated neo-epitope fragment of type IV collagen alpha 3 chain
Measure
ECM remodeling
Conserved in
Human
Note
serum, urine. 50 µl
Biomarker
huARGS
Specification
N-terminal epitope of Aggrecanase mediated degradation of aggrecan
Measure
Cartilage remodeling
Conserved in
Human
Note
serum, 50 µl
Reference
(19;22)
Biomarker
CyARGS
Specification
Aggrecanase mediated degradation of aggrecan (monkey)
Measure
Cartilage remodeling
Conserved in
Monkey
Note
Biomarker
exFFGV
Specification
MMP mediated degradation of aggrecan
Measure
Cartilage remodelling
Conserved in
Human
Note
serum. 50 µl
Biomarker
AGNx1
Specification
C- terminal epitope of aggrecanase mediated degradation og aggrecan
Measure
Cartilage remodelling
Conserved in
Human
Note
serum. 50 µl
Reference
(20)
Biomarker
ELM
Specification
Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin
Measure
ECM remodelling: Elastin degradation
Conserved in
Human
Note
serum, plasma. 50 µl
Reference
(23;24)
Biomarker
EL-NE
Specification
Neo-epitope of neutrophil elastase mediated degradation of elastin
Measure
ECM remodelling: Elastin degradation
Conserved in
Human
Note
serum. 50 µl
Reference
(26)
Biomarker
ELM7
Specification
Neo-epitope of MMP-7 mediated degradation of elastin
Measure
ECM remodelling: Elastin degradation
Conserved in
Human, rat, mouse
Note
serum, plasma. 50 µl
Reference
(25)
Biomarker
ELM12
Specification
Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin
Measure
ECM remodelling: Elastin degradation
Conserved in
Human
Note
50 µl
Reference
(24)
Biomarker
ELP-3
Specification
Neo-epitope of proteinase-3 mediated degradation of elastin
Measure
ECM remodeling: Elastin degradation
Conserved in
Human, mouse, rat
Note
serum, plasma 50 µl
Biomarker
EL-CG
Specification
Neo-epitope of caghepsin G mediated degradation of elastin
Measure
ECM remodeling: Elastin degradation
Conserved in
Human
Note
serum. 50 µl
Biomarker
BGM
Specification
Neo-epitope of MMP-9,12 mediated degradation of biglycan
Measure
ECM remodelling: Biglycan degradation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(27)
Biomarker
VCANM
Specification
Neo-epitope of MMP-8,12 mediated degradation of versican
Measure
ECM remodelling: Versican degradation
Conserved in
Human
Note
serum, Plasma. 50 µl
Reference
(28)
Biomarker
uPERLA
Specification
Neo-epiotpe of ADAMTS mediated degradation of perlecan
Measure
ECM remodeling: Perlecan degradation
Conserved in
Human, rat
Note
urine. 50 µl
Biomarker
BREM
Specification
Brevican degraded by MMPs
Measure
ECM remodelling: Bevican degradation
Conserved in
Human, mouse, rat
Note
50 µl
Biomarker
TIM
Specification
Neo-epiotpe of MMP-12 mediated degradation of titin (Cardiac isoform)
Measure
ECM remodelling: Titin degradation
Conserved in
Human, mouse, rat
Note
serum, 50 µl
Reference
(29)
Biomarker
TIM-2
Specification
Specific fragment of MMP-12-mediated degradation of titin (Muscle isoform)
Measure
ECM remodelling: Titin degradation
Conserved in
Human, mouse, rat
Note
50 µl
Reference
(30)
Biomarker
MIM
Specification
Neo-epitope of MMP-9,12 mediated degradation of mimecan
Measure
ECM remodelling: Mimecan degradation
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(31)
Biomarker
VICM
Specification
Neo- epitope of MMP-2, 8 and trypsin mediated degradation of citrullinated vimentin
Measure
Macrophage marker, Inflammatory marker
Conserved in
Human, mouse, rat
Note
serum, plasma. 50 µl
Reference
(32;33)
Biomarker
CRPM
Specification
Neo-epitope of MMP-1, and -8 mediated degradation of C-reactive protein
Measure
Chronic inflammation marker
Conserved in
Human, mouse
Note
serum, plasma. 50 µl
Reference
(34;35)
Biomarker
LAM-a5
Specification
Neo-epitope of MMP-9 mediated degradation of laminin alpha 5 chain
Measure
ECM remodelling: Basement membrane degradation
Conserved in
Human, mouse
Note
serum, plasma. 50 µl
Biomarker
LG1M
Specification
Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain
Measure
ECM remodeling: Basement membrane degradation
Conserved in
Human, rat, mouse
Note
serum, urine. 50 µl
Biomarker
α-SMA
Specification
Acetylated N-terminal of alpha-smooth muscle actin
Measure
Fibrosis, fibroblast differentiation
Conserved in
Human, mouse, rat
Note
serum, plasma, urine. 50 µl
Biomarker
NIC
Specification
Neo-epitope of cathepsin-S mediated degradation of nidogen
Measure
ECM remodeling: Basement membrane degradation
Conserved in
Human
Note
serum, plasma, urine. 50 µl
Reference
(45)
Biomarker
DCN-CS
Specification
Cathepsin S mediated decorin degradation
Measure
ECM remodeling: Decorin degradation
Conserved in
Human, rat, mouse
Note
serum, urine. 50 µl
Biomarker
FBN-C
Specification
C-terminal of fibronectin
Measure
ECM remodeling: Fibronectin turnover
Conserved in
Not validated
Note
Reference
(36)
Biomarker
BREV-A
Specification
Neo-epitope of ADAMTS-4 mediated degradation of brevican
Measure
Brain ECM remodeling: Brevican degradation
Conserved in
Human
Note
serum. 50 µl
Biomarker
N-BREV
Specification
N-terminal of brevican
Measure
Brain ECM remodeling: Brevican turnover
Conserved in
Human
Note
serum. 50 µl
Biomarker
TAU-A
Specification
Neo-epitope of ADAM-10 mediated degradation of TAU
Measure
Cognitive loss
Conserved in
Human
Note
serum. 50 µl
Reference
(37)
Biomarker
TAU-C
Specification
Neo-epitope of caspase-3 mediated degradation of TAU
Measure
Cognitive loss
Conserved in
Human
Note
serum. 50 µl
Reference
(38)
Biomarker
CTX-I
Specification
Neo-epitope of cathepsin mediated degradation of type I collagen
Measure
Bone resorption
Conserved in
Human, rat
Note
serum, urine. 50 µl
Reference
(43)
Biomarker
CTX-II
Specification
Neo-epitope of MMP mediated degradation of type II collagen
Measure
Cartilage destruction
Conserved in
Human, rat, mouse
Note
50 µl
Reference
(44)
Biomarker
SPARC-M
Specification
Neo-epitope of MMP mediated degracation of SPARC
Measure
ECM remodeling: Collagen binding
Conserved in
Human
Note
serum. 50 µl
Biomarker
IC-6
Specification
Internal fragment of type VI collagen
Measure
ECM remodeling: Collagen degradation
Conserved in
Human
Note
serum. 50 µl
Biomarker
Endostatin
Specification
Neo-epitope of MMP mediated degradation of type XVIII collagen
Measure
ECM remodeling: basement membrane degradation
Conserved in
human
Note
serum, plasma. 50 µl
Biomarker
Restin-1
Specification
Neo-epitope of MMP-mediated degradation of type XV collagen
Measure
ECM remodeling: Basement membrane degradation
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker Specification Measure Conserved in Note Reference
Biomarker
acMMP3
Specification
Activated MMP-3
Measure
Synovial inflammation
Conserved in
Human
Note
serum. 50 µl
Reference
(39)
Biomarker
acCAT-K
Specification
Activated Cathepsin K
Measure
Protease activity: active form of cathepsin K
Conserved in
Human, rat
Note
50 µl
Reference
(40)
Biomarker
acMMP-9
Specification
Activated MMP-9
Measure
Protease activity: active form of MMP-9
Conserved in
Human
Note
Investigation ongoing
Reference
(41)
Biomarker
acMMP13
Specification
N-terminal of active MMP-13
Measure
Protease activity: active form of MMP-13
Conserved in
Human
Note
Investigation ongoing
Reference
(41)
Biomarker
acADAMTS4
Specification
N-terminal of active ADAMTS-4
Measure
Protease activity: active form of ADAMTS-4
Conserved in
Human
Note
Investigation ongoing
Reference
42
Biomarker
acADAMTS5
Specification
N-terminal of active ADAMTS-5
Measure
Protease activity: active form of ADAMTS-5
Conserved in
Human
Note
Investigation ongoing
Reference
41
Biomarker
LOX-L2
Specification
Lysyl oxidase 2
Measure
ECM cross-linking
Conserved in
Human
Note
Investigation ongoing
Biomarker Specification Measure Conserved in Note Reference
Biomarker
F1.2/F2
Specification
Neo-epitope of Fxa/Fva mediated degradation of prothrombin
Measure
thrombin activation
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker
F1
Specification
Neo-epitope of thrombin mediated degradation of prothrombin
Measure
thrombin activation
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker
FPA
Specification
Neo-epitope of thrombin mediated degradation of fibrinogen
Measure
Fibrin formation, fibrinopeptide A released from conversion of fibrinogen into fibrin
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker
FXlll
Specification
Neo-epitope of thrombin mediated degradation of transglutaminase FXIII
Measure
Activation of FXIII, fibrin crosslinking
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker
D-Dimer
Specification
Neo-epitope of plasmin mediated degradation of cross-linked fibrin (sandwich assay)
Measure
Fibrinolysis (fibrin crosslinking)
Conserved in
Human, rat
Note
serum, plasma. 50 µl
Biomarker
D-fragment
Specification
Neo-epitope of plasmin mediated degradation of fibrin
Measure
Fibrinolysis
Conserved in
Human, rat
Note
serum, plasma. 50 µl
Biomarker
VWF-A
Specification
Neo-epitope of ADAMTS13 mediated degradation of von willebrand factor
Measure
Von willebrand factor degradation
Conserved in
Human, Mouse, Rat.
Note
serum, plasma. 50 µl
Biomarker
VWF-N
Specification
Released N-terminal pro-peptide of von willebrand factor
Measure
Von willebrand factor formation
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker
COMP-C5a
Specification
N-terminal anaphylatoxin C5a
Measure
complement activation
Conserved in
Human
Note
serum, plasma. 50 µl
Biomarker Specification Measure Conserved in Note Reference
Biomarker
Adiponetine
Specification
Merck Millipore
Measure
In validation
Conserved in
Human
Note
serum
Biomarker
C2C
Specification
Ibex Pharmaceuticals
Measure
Conserved in
Human
Note
serum
Biomarker
CD14
Specification
R&D systems
Measure
Conserved in
Human
Note
serum
Biomarker
CD163
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
COMP
Specification
IDS
Measure
Conserved in
Human
Note
serum
Biomarker
C-Peptide (R&D)
Specification
R&D Systems
Measure
In validation
Conserved in
Human
Note
serum
Biomarker
CXCL4
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
CXCL13
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
Glucagon
Specification
R&D Systems
Measure
In validation
Conserved in
Human
Note
serum
Biomarker
HA
Specification
Corgenix
Measure
Conserved in
Human
Note
serum
Biomarker
ICAM-1
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
IL-6
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
IL-2 RA
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
IL-22
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
IL-23
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
Leptin
Specification
Merck Millipore
Measure
Conserved in
Human
Note
serum
Biomarker
MDC
Specification
Mesoscale
Measure
Conserved in
Human
Note
serum
Biomarker
Metra U-DPD
Specification
BioCompare
Measure
Conserved in
Human
Note
serum
Biomarker
MMP3
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
MMP9
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
N-MID (osteocalcin
Specification
IDS
Measure
Conserved in
Human
Note
serum
Biomarker
OPG
Specification
BioVendor
Measure
Conserved in
Human
Note
serum
Biomarker
OPG
Specification
IDS
Measure
Conserved in
Human
Note
serum
Biomarker
Ostase BAP
Specification
IDS
Measure
Conserved in
Human
Note
serum
Biomarker
PCIP
Specification
Takara
Measure
Conserved in
Human
Note
serum
Biomarker
PIIANP
Specification
Merck Millipore
Measure
Conserved in
Human
Note
serum
Biomarker
P-PTH
Specification
Biomerica
Measure
Conserved in
Human
Note
plasma
Biomarker
PTHrP
Specification
Roche
Measure
Conserved in
Human
Note
plasma
Biomarker
S-CrossLaps
Specification
IDA
Measure
Conserved in
Human
Note
serum
Biomarker
SNTX
Specification
Osteomark
Measure
Conserved in
Human
Note
serum
Biomarker
TARC
Specification
Merck Millipore
Measure
Conserved in
Human
Note
serum
Biomarker
TNF-alpha
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
TRAcP 5b
Specification
R&D Systems
Measure
Conserved in
Human
Note
serum
Biomarker
uCTX-II
Specification
IDS
Measure
Conserved in
Human
Note
urine
Biomarker
U-NTX
Specification
Osteomark
Measure
Conserved in
Human
Note
urine
Biomarker
Urine-alpha-Crosslab
Specification
IDS
Measure
Conserved in
Human
Note
urine
Biomarker
Urine-beta-Crosslab
Specification
IDS
Measure
Conserved in
Human
Note
urine
Biomarker
Vitamin D
Specification
IDS
Measure
Conserved in
Human
Note
serum
Biomarker
pANCA
Specification
Abexxa
Measure
Validated for plasma
Conserved in
Human
Note
serum and plasma
Biomarker
ASCA IgA
Specification
InovaDx
Measure
vlaidated for plasma
Conserved in
Human
Note
serum and plasma
Biomarker
ALB
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
BILI
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
DBILI_2
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
CRE_2
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
IP
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
TP2
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
UA
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
UN
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
NA
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
K
Specification
Siemens
Measure
Siemens advia 1800
Conserved in
Human
Note
serum
Biomarker
Cl-
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
CO2
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
CA
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
CHOL_2
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
Gluc_3
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
MG
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
TRIG
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum, plasma (heparin)
Biomarker
ALP_2c
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
GGT
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
LDLP
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
ALT
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
AST
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
CK_L
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
D-LDL Chol
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
D-HDL Chol
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
APO B
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
APO A1
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
hs CRP
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum, plasma (EDTA)
Biomarker
RF
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
CA
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
urine
Biomarker
CREA
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
urine
Biomarker
Phosphate
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
urine
Biomarker
HbA1c
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
blood
Biomarker
Amylase
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
Lipase
Specification
Siemens
Measure
Siemens Advia 1800
Conserved in
Human
Note
serum
Biomarker
PTH
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
N-MID
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
β-CrossLaps
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
PINP
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
Insulin
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
HCG
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
HIV Combi
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
HBsAg II
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
Anti HCV
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
Anti CCP
Specification
Roche
Measure
Cobas
Conserved in
Human
Note
serum
Biomarker
WBC
Specification
sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
RBC
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
HGB
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
HCT
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
MCV
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
MCH
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
MCHC
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
PLT
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
RDW-CV
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
NEUT
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
LYMPH
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
MONO
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
EO
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
BASO
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
IG
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
Biomarker
RET
Specification
Sysmex
Measure
Sysmex
Conserved in
Human
Note
blood
  1. Leeming,D.J., Larsen,D.V., Zhang,C., Hi,Y., Veidal,S.S., Nielsen,R.h., Henriksen,K., Zheng,Q., Barkholt,V., Riis,B.J. et al 2010. Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP)--assessment of corresponding epitopes. Clin. Biochem. 43:1249-1256.

  2. Gudmann,N.S., Wang,J., Hoielt,S., Chen,P., Siebuhr,A.S., He,Y., Christiansen,T.G., Karsdal,M.A., and Bay-Jensen,A.C. 2014. Cartilage turnover reflected by metabolic processing of type II collagen: a novel marker of anabolic function in chondrocytes. Int. J. Mol. Sci. 15:18789-18803.

  3. Nielsen,M.J., Nedergaard,A.F., Sun,S., Veidal,S.S., Larsen,L., Zheng,Q., Suetta,C., Henriksen,K., Christiansen,C., Karsdal,M.A. et al 2013. The neo-epitope specific PRO-C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters. Am. J. Transl. Res. 5:303-315.

  4. Leeming,D.J., Karsdal,M.A., Rasmussen,L.M., Scholze,A., and Tepel,M. 2013. Association of Systemic Collagen Type IV Formation with Survival among Patients Undergoing Hemodialysis. PLoS. ONE. 8:e71050.

  5. Vassiliadis,E., Veidal,S.S., Simonsen,H., Larsen,D.V., Vainer,B., Chen,X., Zheng,Q., Karsdal,M.A., and Leeming,D.J. 2011. Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodelling associated with liver fibrosis. Biomarkers.

  6. Leeming,D.J., Veidal,S.S., Karsdal,M.A., Nielsen,M.J., Trebicka,J., Busk,T., Bendtsen,F., Krag,A., and Moller,S. 2015. Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis. Scand. J. Gastroenterol. 50:584-592.

  7. Sun,S., Henriksen,K., Karsdal,M.A., Byrjalsen,I., Rittweger,J., Armbrecht,G., Belaw,D.L., Felsenberg,D., Nedergaard,A.F. 2015. Collagen type III and VI turnover in response to long-term immobilization. PLoS One. 10(12):e0144525.

  8. Leeming,D., He,Y., Veidal,S., Nguyen,Q., Larsen,D., Koizumi,M., Segovia-Silvestre,T., Zhang,C., Zheng,Q., Sun,S. et al 2011. A novel marker for assessment of liver matrix remodelling: An enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M). Biomarkers.

  9. Siebuhr,A.S., Bay-Jensen,A.C., Leeming,D.J., Platt,A., Byrjalsen,I., Christiansen,C., van der,H.D., and Karsdal,M. 2013. Serological identification of fast progressors of structural damage with rheumatoid arthritis. Arthritis Res. Ther. 15:R86.

  10. Bay-Jensen,A.C., Liu,Q., Byrjalsen,I., Li,Y., Wang,J., Pedersen,C., Leeming,D.J., Dam,E.B., Zheng,Q., Qvist,P. et al 2011. Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis. Clin. Biochem. 44:423-429.

  11. Barascuk,N., Veidal,S.S., Larsen,L., Larsen,D.V., Larsen,M.R., Wang,J., Zheng,Q., Xing,R., Cao,Y., Rasmussen,L.M. et al 2010. A novel assay for extracellular matrix remodelling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen. Clin. Biochem.

  12. Bay-Jensen,A.C., Platt,A., Byrjalsen,I., Vergnoud,P., Christiansen,C., and Karsdal,M.A. 2013. Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study. Semin. Arthritis Rheum.

  13. Sand,J.M., Larsen,L., Hogaboam,C., Martinez,F., Han,M., Rossel,L.M., Nawrocki,A., Zheng,Q., Karsdal,M.A., and Leeming,D.J. 2013. MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodelling in experimental and clinical fibrosis--validation of two novel biomarker assays. PLoS. ONE. 8:e84934.

  14. Veidal,S.S., Larsen,D.V., Chen,X., Sun,S., Zheng,Q., Bay-Jensen,A.C., Leeming,D.J., Nawrocki,A., Larsen,M.R., Schett,G. et al 2012. MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis. Clin. Biochem. 45:541-546.

  15. Veidal,S.S., Karsdal,M.A., Vassiliadis,E., Nawrocki,A., Larsen,M.R., Nguyen,Q.H., Hagglund,P., Luo,Y., Zheng,Q., Vainer,B. et al 2011. MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis - Identification and Validation of a Novel Biochemical Marker Assay. PLoS. ONE. 6:e24753.

  16. Nedergaard,A., Sun,S., Karsdal,M.A., Henriksen,K., Kjaer,M., Lou,Y., He,Y., Zheng,Q., and Suetta,C. 2013. Type VI collagen turnover-related peptides-novel serological biomarkers of muscle mass and anabolic response to loading in young men. J. Cachexia. Sarcopenia. Muscle.

  17. Hansen,N.U., Willumsen,N., Sand,J.M., Larsen,L., KArsdal,M.A., Leeming,D.J. 2016. Type VIII collagen is elevated in diseases with angiogenesis and vascular remodeling. Clin Biochem. 49(12):903-8.

  18. He,Y., Siebuhr,A.S., Brandt-Hansen,N.U., Wang,J., Su,D., Zheng,Q., Simonsen,O., Petersen,K.K., rendt-Nielsen,L., Eskehave,T. et al 2014. Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation. BMC. Musculoskelet. Disord. 15:309.

  19. Karsdal,M.A., Sumer,E.U., Wulf,H., Madsen,S.H., Christiansen,C., Fosang,A.J., and Sondergaard,B.C. 2007. Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum 56:1549-1558.

  20. Karsdal,M.A., Madsen,S.H., Christiansen,C., Henriksen,K., Fosang,A.J., and Sondergaard,B.C. 2008. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res. Ther. 10:R63.

  21. Madsen,S.H., Sumer,E.U., Bay-Jensen,A.C., Sondergaard,B.C., Qvist,P., and Karsdal,M.A. 2010. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo. Biomarkers 15:266-276.

  22. Rousseau,J.C., Sumer,E.U., Hein,G., Sondergaard,B.C., Madsen,S.H., Pedersen,C., Neumann,T., Mueller,A., Qvist,P., Delmas,P. et al 2008. Patients with rheumatoid arthritis have an altered circulatory aggrecan profile. BMC. Musculoskelet. Disord. 9:74.

  23. Skjot-Arkil,H., Clausen,R.E., Nguyen,Q.H., Wang,Y., Zheng,Q., Martinez,F.J., Hogaboam,C.M., Han,M., Klickstein,L.B., Larsen,M.R. et al 2012. Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC. Pulm. Med. 12:34.

  24. Skjot-Arkil,H., Clausen,R.E., Rasmussen,L.M., Wang,W., Wang,Y., Zheng,Q., Mickley,H., Saaby,L., Diederichsen,A.C., Lambrechtsen,J. et al 2013. Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin as Quantified by Two Novel ELISAs. PLoS. ONE. 8:e60936.

  25. Kristensen,J.H., Larsen,L., Dasgupta,B., Brodmerkel,C., Curran,M., Karsdal,M.A., Sand,J.M., Willumsen,N., Knox,A.J., Bolton,C.E. et al 2015. Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders. Clin Biochem. 48(16-17):1083-8.

  26. Kristensen,J.H., Karsdal,M.A., Sand,J.M., Willumsen,N., Diefenbach,C., Svensson,B., Hagglund,P., and Oersnes-Leeming,D.J. 2015. Serological assessment of neutrophil elastase activity on elastin during lung ECM remodelling. BMC. Pulm. Med. 15:53.

  27. Genovese,F., Barascuk,N., Larsen,L., Larsen,M.R., Nawrocki,A., Li,Y., Zheng,Q., Wang,J., Veidal,S.S., Leeming,D.J. et al 2013. Biglycan fragmentation in pathologies associated with extracellular matrix remodelling by matrix metalloproteinases. Fibrogenesis. Tissue Repair 6:9.

  28. Barascuk,N., Genovese,F., Larsen,L., Byrjalsen,I., Zheng,Q., Sun,S., Hosbond,S., Poulsen,T.S., Diederichsen,A., Jensen,J.M. et al 2013. A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease. Int. J. Clin. Exp. Med. 6:174-184.

  29. Vassiliadis,E., Rasmussen,L.M., Byrjalsen,I., Larsen,D.V., Chaturvedi,R., Hosbond,S., Saabye,L., Diederichsen,A.C., Genovese,F., Duffin,K.L. et al 2012. Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker. J. Transl. Med. 10:140.

  30. Sun,S., Henriksen,K., Karsdal,M.A., Armbrecht,G., Belavy,D.L., Felsenberg,D., Rittweger,J., Wang,Y., Zheng,Q., and Nedergaard,A.F. 2014. Measurement of a MMP-2 degraded Titin fragment in serum reflects changes in muscle turnover induced by atrophy. Exp. Gerontol. 58C:83-89.

  31. Barascuk,N., Vassiliadis,E., Zheng,Q., Wang,Y., Wang,W., Larsen,L., Rasmussen,L.M., and Karsdal,M.A. 2011. Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodelling in Apolipoprotein E Knockout Mice. Biomark. Insights. 6:97-106.

  32. Vassiliadis,E., Oliveira,C.P., vares-da-Silva,M.R., Zhang,C., Carrilho,F.J., Stefano,J.T., Rabelo,F., Pereira,L., Kappel,C.R., Henriksen,K. et al 2012. Circulating levels of citrullinated and MMP-degraded vimentin (VICM) in liver fibrosis related pathology. Am. J. Transl. Res. 4:403-414.

  33. Bay-Jensen,A.C., Karsdal,M.A., Vassiliadis,E., Wichuk,S., Marcher-Mikkelsen,K., Lories,R., Christiansen,C., and Maksymowych,W.P. 2013. Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression. Arthritis Rheum 65:972-980.

  34. Skjot-Arkil,H., Schett,G., Zhang,C., Larsen,D.V., Wang,Y., Zheng,Q., Larsen,M.R., Nawrocki,A., Bay-Jensen,A.C., Henriksen,K. et al 2012. Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis. Clin. Exp. Rheumatol.

  35. Bay-Jensen,A.C., Platt,A., Byrjalsen,I., Vergnoud,P., Christiansen,C., and Karsdal,M.A. 2013. Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study. Semin. Arthritis Rheum.

  36. Bager,C.L., Gudmann,N., Willumsen,N., Leeming,D.J., Karsdal,M.A., Bay-Jensen,A.C., Høgdall,E., Balslev,I., He,Y. Quantification of fibronectin as a method to assess ex vivo extracellular matrix remoeling. 2016. Biochem Biophys Res Commun. Sep 16;478(2):586-91.

  37. Henriksen,K., Wang,Y., Sorensen,M.G., Barascuk,N., Suhy,J., Pedersen,J.T., Duffin,K.L., Dean,R.A., Pajak,M., Christiansen,C. et al 2013. An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function. PLoS. ONE. 8:e64990.

  38. Shahim,P., Linemann,T., Inekci,D., Karsdal,M.A., Blennow,K., Tegner,Y., Zetterberg,H., and Henriksen,K. 2016. Serum tau fragments predict return to play in concussed professional ice hockey players. J. Neurotrauma. Nov 15;33(22):1995-9.

  39. Sun,S., Bay-Jensen,A.C., Karsdal,M.A., Siebuhr,A.S., Zheng,Q., Maksymowych,W.P., Christiansen,T.G., and Henriksen,K. 2014. The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases. BMC. Musculoskelet. Disord. 15:93.

  40. Sun,S., Karsdal,M.A., Bay-Jensen,A.C., Sorensen,M.G., Zheng,Q., Dziegiel,M.H., Maksymowych,W.P., and Henriksen,K. 2013. The development and characterization of an ELISA specifically detecting the active form of cathepsin K. Clin. Biochem. Oct;46(15):1601-6.

  41. He,Y., Zheng,Q., Jiang,M., Sun,S., Christiansen,T.G., Kassem,M., Karsdal,M.A., Bay-Jensen,A.C. 2015. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE.Apr 24;10(4).

  42. He,Y., Zheng,Q., Simonsen,O., Petersen,K.K., Christiansen,T.G., Karsdal,M.A., Bay-Jensen,A.C. 2013. The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model. Matrix Biol. Apr 24;32(3-4):143-51.

  43. Rosenquist,C., Qvist,P., Bjarnason,N., and Christiansen,C. 1995. Measurement of a more stable region of osteocalcin in serum by ELISA with two monoclonal antibodies. Clin Chem 41:1439-1445.

  44. Reijman,M., Hazes,J.M., Bierma-Zeinstra,S.M., Koes,B.W., Christgau,S., Christiansen,C., Uitterlinden,A.G., and Pols,H.A. 2004. A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 50:2471-2478.

  45. Willumsen N, Bager CL, Leeming DJ, Bay-Jensen A-C, Karsdal MA. 2017. Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non–Small Cell Lung Cancer. Neoplasia 19:271–278

  46. Bay-Jensen A.C., Kjelgaard-Petersen C.F., Petersen K.K., Arendt-Nielsen L., Quasnichka H.L., Mobasheri A., Karsdal M.A. 2018. Aggrecanase degradation of type III collagen is associated with clinical knee pain. Clin Biochem. 58:37-43

  47. Hansen N.U., Willumsen N., Sand J.M., Larsen L., Karsdal M.A., Leeming D.J. 2016. Type VIII collagen is elevated in diseases associated with angiogenesis and vascular remodeling. Clin Biochem. 12: 903-908

  48. Jensen C., Nielsen S.H., Mortensen J.H., Kjeldsen J., Klinge L.G., Krag A., Harling H., Jørgensen L.N, Karsdal M.A., Willumsen N. 2018. Serum type XVI collagen is associated with colorectal cancer and ulcerative colitis indicating a pathological role in gastrointestinal disorders. Cancer Med.